The purpose of this study was to determine the effects of two different HBO (hyperbaric oxygen) exposures on body surface temperature. Eight healthy male collegiate students participated in this study (age: 21.0±0 year, height: 170.6±2.6 cm, body weight: 61.3±3.8 kg, BMI: 23.4±1.4 kg/m2). All subjects were divided into the (i) Mild HBOT (n=8, HBO treatment: 50%O2 at 1.3ATA for 60 min) and (ii) control (n=8, HBO treatment: 50%O2 at 1.0ATA for 60 min) groups. Body surface temperature was measured at peripheral part of upper extremity before and after each treatment. No significant differences were observed in the Mild HBOT group before and after the treatment (0.04±1.38℃). In contrast, body surface temperature was significantly increased in the control group after the treatment (2.7±4.7℃, p<0.05). The results of the present study indicate that mild HBOT can cause less effect on body and consequently be more effective compared with controls, taking into consideration optimal hyperbaric oxygen therapy.